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Born seemingly healthy, her mother Kerry became worried when at 13 months, her daughter stopped speaking, started wringing her hands and screaming constantly in pain. She is pictured using her computer 

During the first stage, from about the age of six to 18 months, a baby slows in development, loses interest in play, stops making eye contact, starts walking awkwardly and makes repetitive hand movements.

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'We hang on to the hope, however small, that we will see Madeleine again. As we have said repeatedly, we need to know what has happened to our lovely daughter, no matter what. We are very grateful to the police for their continued efforts.'

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Brueckner also is alleged to have admitted abducting Madeleine to a friend - and the German team of investigators, led by public prosecutor Hans Christian Wolters, said they were certain he had killed the three-year-old.

Detectives are said to be frustrated by the failure to compile sufficient evidence to prosecute Christian Brueckner (pictured), a convicted paedophile, who was named two years ago by German police as the prime suspect for Madeleine's abduction

'The letter did not state that there was evidence or proof that Madeleine is dead, the MPS continues to investigate Madeleine's disappearance as a missing person investigation. No letter has been received by the Met from the German prosecutor.'

The Sun claimed last night that funding for the Operation Grange inquiry - launched four years after the Portuguese police began their unsuccessful search for the youngster in 2007 - will end later this year unless new lines of inquiry emerge.

Brueckner also is alleged to have admitted abducting Madeleine to a friend - and the German team of investigators, led by public prosecutor Hans Christian Wolters (above), said they were certain he had killed the three-year-old

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Lily was diagnosed with Rett syndrome - a cruel, life-limiting disease - following a year of tests.The condition, which affects the development of the brain, can cause severe physical and mental disability

He was last year found guilty of the 2005 rape of a 72-year-old American woman in the same Portuguese resort from which Madeleine vanished and sentenced to seven years in jail, at a court in Brunswick, Lower Saxony.

The disappearance was reported immediately and a search party launched the same evening including officers from the Guarda Nacional Republicana and the Polícia Judiciária, which launched an investigation.

Detectives are said to be frustrated by the failure to compile sufficient evidence to prosecute Christian Brueckner, a convicted paedophile, who was named two years ago by German police as the prime suspect for Madeleine's abduction.

Scotland Yard is set to wind up its investigation into Madeleine McCann's disappearance, according to reports. The Sun claimed last night that funding for the Operation Grange inquiry - launched four years after the Portuguese police began their unsuccessful search for the youngster in 2007 - will end later this year unless new lines of inquiry emerge